Lucas Oil Stadium

    8:15 PM ET (ESPN)
    ScoreLineOURecordATSO-U-PPFPAEST ScoreEST Line
     49ers
    0
    -3
    9-48-5-07-6-023.620.7
    0
    0
     Colts
    0
    +3
    46.5
    8-47-5-06-6-029.820.8
    0
    0


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    2025 Recent Results
    San FranciscoDraftKingsResultsMoney LineSpreadOVER Total
    WkDateOpponentMLLineOUScoreSUATSOUHandleBetsHandleBetsHandleBets
    Nov 30 at  Cleveland
    -250
    -5.5
    35.5
    26-8
    W
    W
    U
    64%
    76%
    55%
    52%
    35%
    62%
    Nov 24 VS  Carolina
    -395
    -7.5
    49.5
    20-9
    W
    W
    U
    63%
    83%
    46%
    51%
    74%
    53%
    Nov 16 at  Arizona
    -185
    -3.5
    48.5
    41-22
    W
    W
    O
    92%
    88%
    72%
    75%
    68%
    40%
    Nov 9 VS  LA Rams
    +210
    +5.5
    49.5
    26-42
    L
    L
    O
    32%
    22%
    40%
    48%
    52%
    53%
    Nov 2 at  NY Giants
    -148
    -2.5
    47.5
    34-24
    W
    W
    O
    72%
    76%
    73%
    75%
    56%
    39%
    Oct 26 at  Houston
    +130
    +2.5
    41.5
    15-26
    L
    L
    U
    42%
    77%
    29%
    71%
    82%
    67%
    Oct 19 VS  Atlanta
    -115
    -1.5
    46.5
    20-10
    W
    W
    U
    49%
    52%
    57%
    55%
    74%
    56%
    Oct 12 at  Tampa Bay
    +164
    +3.5
    47.5
    19-30
    L
    L
    O
    40%
    27%
    51%
    46%
    87%
    75%
    Oct 2 at  LA Rams
    +350
    +7.5
    43.5
    26-23
    W
    W
    O
    20%
    16%
    43%
    43%
    60%
    50%
    Sep 28 VS  Jacksonville
    -180
    -3.5
    45.5
    21-26
    L
    L
    O
    57%
    78%
    25%
    54%
    60%
    35%
    Sep 21 VS  Arizona
    -122
    -1.5
    44.5
    16-15
    W
    L
    U
    52%
    61%
    64%
    58%
    69%
    64%
    Sep 14 at  New Orleans
    -166
    -3
    40.5
    26-21
    W
    W
    O
    66%
    80%
    69%
    72%
    53%
    46%
    Sep 7 at  Seattle
    -135
    -2.5
    43.5
    17-13
    W
    W
    U
    62%
    71%
    64%
    65%
    64%
    59%

    2025 Recent Results
    IndianapolisDraftKingsResultsMoney LineSpreadOVER Total
    WkDateOpponentMLLineOUScoreSUATSOUHandleBetsHandleBetsHandleBets
    Nov 30 VS  Houston
    -170
    -3
    44.5
    16-20
    L
    L
    U
    54%
    68%
    52%
    55%
    31%
    47%
    Nov 23 at  Kansas City
    +185
    +4.5
    50.5
    20-23
    L
    W
    U
    28%
    44%
    37%
    58%
    39%
    49%
    Nov 9 (n)  Atlanta
    -310
    -6.5
    48.5
    31-25
    W
    L
    O
    64%
    89%
    63%
    70%
    68%
    48%
    Nov 2 at  Pittsburgh
    -175
    -3
    51.5
    20-27
    L
    L
    U
    53%
    76%
    51%
    69%
    75%
    66%
    Oct 26 VS  Tennessee
    -1600
    -15.5
    47.5
    38-14
    W
    W
    O
    66%
    93%
    71%
    67%
    72%
    59%
    Oct 19 at  LA Chargers
    +120
    +2.5
    49.5
    38-24
    W
    W
    O
    32%
    60%
    44%
    57%
    76%
    66%
    Oct 12 VS  Arizona
    -455
    -8.5
    46.5
    31-27
    W
    L
    O
    80%
    91%
    68%
    67%
    64%
    62%
    Oct 5 VS  Las Vegas
    -360
    -7
    46.5
    40-6
    W
    W
    U
    79%
    92%
    67%
    65%
    84%
    60%
    Sep 28 at  LA Rams
    +154
    +3.5
    49.5
    20-27
    L
    L
    U
    39%
    32%
    57%
    51%
    77%
    64%
    Sep 21 at  Tennessee
    -250
    -6
    42.5
    41-20
    W
    W
    O
    83%
    90%
    62%
    62%
    51%
    70%
    Sep 14 VS  Denver
    +105
    +1.5
    43.5
    29-28
    W
    W
    O
    55%
    37%
    44%
    34%
    54%
    52%
    Sep 7 VS  Miami
    -112
    -1.5
    47.5
    33-8
    W
    W
    U
    52%
    30%
    36%
    30%
    47%
    41%

    Last 5 Head to Head Results
    DateRoad/HomeScoreLineMLOUSUATSF/DH/AOU

    2021
    Oct 24
    Indianapolis Colts Indianapolis Colts
    San Francisco 49ers San Francisco 49ers
    30


    18
    +3.5


    -3.5
    +165


    -190
    41.5
    IND

     
    IND

     
    DOG
    Road

     
    Over

    2017
    Oct 8
    San Francisco 49ers San Francisco 49ers
    Indianapolis Colts Indianapolis Colts
    23


    26
    +1


    -1
    +100


    -120
    44
    IND

     
    IND

     
    FAV
    HOME

     
    Over

    2013
    Sep 22
    Indianapolis Colts Indianapolis Colts
    San Francisco 49ers San Francisco 49ers
    27


    7
    +10.5


    -10.5
    +390


    -500
    45.5
    IND

     
    IND

     
    DOG
    Road

     
    Under

    2009
    Nov 1
    San Francisco 49ers San Francisco 49ers
    Indianapolis Colts Indianapolis Colts
    14


    18
    +12.5


    -12.5
    +575


    -725
    45
    IND

     
    SFO

     
    DOG
    Road

     
    Under

    2005
    Oct 9
    Indianapolis Colts Indianapolis Colts
    San Francisco 49ers San Francisco 49ers
    28


    3
    -16.5


    +16.5
    -


    -
    45.5
    IND

     
    IND

     
    FAV
    Road

     
    Under



    Statistic Breakdown
    Offensive Statistics
    SFO SFOStatisticIND INDEdgeMargin
    13
    Games
    12
    SFO SFO
    1
    23.6
    Points Scored
    29.8
    IND IND
    6.1
    242.6
    Passing Yards
    241.0
    SFO SFO
    1.6
    10.3
    PYPC
    11.3
    IND IND
    1.0
    7.0
    PYPA
    7.6
    IND IND
    0.6
    68.2
    Completion PCT
    67.3
    SFO SFO
    0.9
    98.5
    Rushing Yards
    134.4
    IND IND
    35.9
    3.5
    RYPA
    5.1
    IND IND
    1.6
    38.4
    PenaltyYards
    53.3
    SFO SFO
    15.0
    1.4
    Turnovers
    1.0
    IND IND
    0.4
    Defensive Statistics
    SFO SFOStatisticIND INDEdgeMargin
    13
    Games
    12
    IND IND
    1
    20.7
    Points Scored
    20.8
    SFO SFO
    0.1
    232.0
    Passing Yards
    246.3
    SFO SFO
    14.3
    9.7
    PYPC
    10.1
    SFO SFO
    0.4
    6.7
    PYPA
    6.5
    IND IND
    0.2
    69.2
    Completion PCT
    63.9
    IND IND
    5.3
    103.8
    Rushing Yards
    98.3
    IND IND
    5.5
    4.2
    RYPA
    3.9
    IND IND
    0.3
    43.7
    PenaltyYards
    54.3
    IND IND
    10.6
    1.1
    Turnovers
    1.4
    IND IND
    0.3

    Statistic Breakdown
    Offensive Statistics
    SFO SFOStatisticIND INDEdgeMargin
    8
    Games
    6
    SFO SFO
    2
    25.5
    Points Scored
    31.2
    IND IND
    5.7
    238.0
    Passing Yards
    240.8
    IND IND
    2.8
    10.3
    PYPC
    11.8
    IND IND
    1.5
    7.0
    PYPA
    7.9
    IND IND
    1.0
    67.5
    Completion PCT
    67.2
    SFO SFO
    0.3
    91.3
    Rushing Yards
    136.5
    IND IND
    45.3
    3.3
    RYPA
    5.0
    IND IND
    1.7
    37.5
    PenaltyYards
    49.2
    SFO SFO
    11.7
    0.9
    Turnovers
    0.2
    IND IND
    0.7
    Defensive Statistics
    SFO SFOStatisticIND INDEdgeMargin
    8
    Games
    6
    IND IND
    2
    20.9
    Points Scored
    17.2
    IND IND
    3.7
    252.8
    Passing Yards
    220.8
    IND IND
    31.9
    9.8
    PYPC
    9.7
    IND IND
    0.2
    7.2
    PYPA
    6.2
    IND IND
    1.0
    73.1
    Completion PCT
    64.0
    IND IND
    9.0
    104.4
    Rushing Yards
    101.8
    IND IND
    2.6
    4.2
    RYPA
    4.2
    SFO SFO
    0.1
    46.9
    PenaltyYards
    57.8
    IND IND
    11.0
    1.4
    Turnovers
    1.5
    IND IND
    0.1

    Statistic Breakdown
    Offensive Statistics
    SFO SFOStatisticIND INDEdgeMargin
    10
    Games
    10
    -
    0
    24.8
    Points Scored
    29.5
    IND IND
    4.7
    234.0
    Passing Yards
    232.4
    SFO SFO
    1.6
    10.3
    PYPC
    11.0
    IND IND
    0.7
    7.0
    PYPA
    7.3
    IND IND
    0.3
    68.1
    Completion PCT
    66.5
    SFO SFO
    1.6
    101.2
    Rushing Yards
    129.0
    IND IND
    27.8
    3.6
    RYPA
    5.3
    IND IND
    1.7
    32.9
    PenaltyYards
    52.7
    SFO SFO
    19.8
    1.4
    Turnovers
    1.2
    IND IND
    0.2
    Defensive Statistics
    SFO SFOStatisticIND INDEdgeMargin
    10
    Games
    10
    -
    0
    22.0
    Points Scored
    21.3
    IND IND
    0.7
    253.0
    Passing Yards
    261.6
    SFO SFO
    8.6
    10.2
    PYPC
    10.4
    SFO SFO
    0.3
    7.1
    PYPA
    6.6
    IND IND
    0.4
    69.4
    Completion PCT
    63.4
    IND IND
    6.0
    103.8
    Rushing Yards
    98.3
    IND IND
    5.5
    4.3
    RYPA
    3.7
    IND IND
    0.6
    46.3
    PenaltyYards
    55.3
    IND IND
    9.0
    1.1
    Turnovers
    1.3
    IND IND
    0.2

    Statistic Breakdown
    Offensive Statistics
    SFO SFOStatisticIND INDEdgeMargin
    6
    Games
    6
    -
    0
    17.5
    Points Scored
    25.0
    IND IND
    7.5
    173.2
    Passing Yards
    257.5
    IND IND
    84.3
    10.4
    PYPC
    10.9
    IND IND
    0.5
    5.9
    PYPA
    7.1
    IND IND
    1.3
    56.5
    Completion PCT
    65.4
    IND IND
    8.9
    118.2
    Rushing Yards
    133.2
    IND IND
    15.0
    5.1
    RYPA
    4.2
    SFO SFO
    0.9
    65.8
    PenaltyYards
    52.5
    IND IND
    13.3
    2.3
    Turnovers
    1.8
    IND IND
    0.5