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    2. NFL
    3. Matchup Report - San Francisco 49ers at Indianapolis Colts

    Monday,December 22
     49ers at  Colts
    Lucas Oil Stadium
    FINAL
    		ScoreLineOURecordATSO-U-PPFPAEST ScoreEST Line
     49ers
    48
    -4.5
    		10-49-5-08-6-024.620.9
    27.3
    45.4
     Colts
    27
    +4.5
    46.5
    		8-68-6-07-7-028.021.6
    18.1
    9.3
     
    DraftKings Betting Splits
    Monday,Dec 22SpreadHandleBetsTotalHandleBetsMoneyHandleBets
     San Francisco 49ers
     Indianapolis Colts
    -4.5
    +4.5
    60%
    40%
    71%
    29%
    46.5
    46.5
    70%
    30%  
    53%
    47%
    -225
    +185
    65%
    35%
    76%
    24%
    Circa Sports Betting Splits
    Monday,Dec 22SpreadHandleBetsTotalHandleBetsMoneyHandleBets
     San Francisco 49ers
     Indianapolis Colts
    -4
    +4
    37%  
    63%
    78%
    22%
    46.5
    46.5
    59%
    41%
    47%  
    53%
    -210
    180
    83%  
    17%
    49%
    51%
    Pro Picks at a Glance
    VSiN ExpertSportEvent DateSelectionScoreResult
    Tom Brolley
    		 NFL2025-12-22Philip Rivers (Colts) OVER 17.5 Passing Completions (-118)
    23
    WIN
    Tom Brolley
    		 NFL2025-12-22Kendrick Bourne (49ers) OVER 21.5 Receiving Yards (-115)
    27
    WIN
    John Hansen
    		 NFL2025-12-22Tyler Warren (Colts) OVER 33.5 Receiving Yards (-112)
    30
    LOSS
    John Hansen
    		 NFL2025-12-22Jonathan Taylor (Colts) OVER 18.5 Receiving Yards (-110)
    33
    WIN
    John Hansen
    		 NFL2025-12-22Philip Rivers (Colts) OVER 18.5 Passing Completions (+100)
    23
    WIN
    John Hansen
    		 NFL2025-12-22Alec Pierce (Colts) OVER 19.5 Receiving Yards (-118)
    86
    WIN
    John Hansen
    		 NFL2025-12-22Jauan Jennings (49ers) OVER 54.5 Receiving Yards (-113)
    71
    WIN
    John Hansen
    		 NFL2025-12-22George Kittle (49ers) OVER 67.5 Receiving Yards (-114)
    115
    WIN
    John Hansen
    		 NFL2025-12-22Tyler Warren (Colts) Anytime TD (+235)
    0
    LOSS
    Nick Whalen
    		 NFL2025-12-22George Kittle (49ers) OVER 5.5 Receptions (-120)
    7
    WIN
    Mitch Moss
    		 NFL2025-12-22Jonathan Taylor (Colts) OVER 17.5 Rushing Long (-110)
    7
    LOSS
    Warren Sharp
    		 NFL2025-12-22Brock Purdy (49ers) OVER 7.5 Rushing Long (-120)
    9
    WIN
    Marc Malusis
    		 NFL2025-12-22Colts (+5.5) (-110) vs 49ers
    27 - 48
    LOSS
    Jensen Lewis
    		 NFL2025-12-22Colts (+6) (-137) vs 49ers
    27 - 48
    LOSS
    Will Hill
    		 NFL2025-12-22Team Total - Colts UNDER (21) (-110) vs 49ers
    27
    LOSS
    Warren Sharp
    		 NFL2025-12-22Jonathan Taylor (Colts) OVER 17.5 Rushing Long (-120)
    7
    LOSS
    Scott Seidenberg
    		 NFL2025-12-22Philip Rivers (Colts) UNDER 26.5 Passing Long (-115)
    33
    LOSS
    Jensen Lewis
    		 NFL2025-12-2249ers at Colts - UNDER (46.5) (-120)
    75
    LOSS
    Zachary Cohen
    		 NFL2025-12-2249ers at Colts - OVER (44.5) (-128)
    75
    WIN
    Patrick Meagher
    		 NFL2025-12-22Colts (+6) (-108) vs 49ers
    27 - 48
    LOSS
    Ryan Kramer
    		 NFL2025-12-2249ers (-5.5) (-110) at Colts
    48 - 27
    WIN
    Matt Youmans
    		 NFL2025-12-22Colts (+6) (-110) vs 49ers
    27 - 48
    LOSS
    Jensen Lewis
    		 NFL2025-12-221H - 49ers (-2.5) at Colts
    24 - 17
    WIN
    Chris Macero
    		 NFL2025-12-2249ers at Colts - OVER (46.5)
    75
    WIN
    Chris Piper
    		 NFL2025-12-2249ers at Colts - UNDER (46.5)
    75
    LOSS
    Chris Piper
    		 NFL2025-12-2249ers (-5.5) at Colts
    48 - 27
    WIN
    Betti / Curtis
    		 NFL2025-12-22Colts (+5.5) vs 49ers
    27 - 48
    LOSS
    Jason Jarvis
    		 NFL2025-12-22Colts (+5.5) vs 49ers
    27 - 48
    LOSS
    Wes Reynolds
    		 NFL2025-12-22Colts (+7) (-120) vs 49ers
    27 - 48
    LOSS
    Makinen Weekly Ratings
    DraftKingsPower RatingsEffective StrengthBettor Rating
     Monday, December 22ScoreLineOUPRLineScoreProjEdgeScoreProjEdge
    San Francisco 49ers San Francisco 49ers
    48
    -4.5
    28.0
    27.3
    45.4
    24.1
    43.6
    Indianapolis Colts Indianapolis Colts
    27
    +4.5
    46.5
    27.5
    4.7
    18.1
    9.3
    19.5
    4.6
      
    2025 Recent Results
    San FranciscoDraftKingsResultsMoney LineSpreadOVER Total
    WkDateOpponentMLLineOUScoreSUATSOUHandleBetsHandleBetsHandleBets
    15
    		Dec 14 VS  Tennessee
    -950
    -12.5
    44.5
    37-24
    W
    W
    O
    85%
    95%
    80%
    77%
    82%
    54%
    13
    		Nov 30 at  Cleveland
    -250
    -5.5
    35.5
    26-8
    W
    W
    U
    64%
    76%
    55%
    52%
    35%
    62%
    12
    		Nov 24 VS  Carolina
    -395
    -7.5
    49.5
    20-9
    W
    W
    U
    63%
    83%
    46%
    51%
    74%
    53%
    11
    		Nov 16 at  Arizona
    -185
    -3.5
    48.5
    41-22
    W
    W
    O
    92%
    88%
    72%
    75%
    68%
    40%
    10
    		Nov 9 VS  LA Rams
    +210
    +5.5
    49.5
    26-42
    L
    L
    O
    32%
    22%
    40%
    48%
    52%
    53%
    9
    		Nov 2 at  NY Giants
    -148
    -2.5
    47.5
    34-24
    W
    W
    O
    72%
    76%
    73%
    75%
    56%
    39%
    8
    		Oct 26 at  Houston
    +130
    +2.5
    41.5
    15-26
    L
    L
    U
    42%
    77%
    29%
    71%
    82%
    67%
    7
    		Oct 19 VS  Atlanta
    -115
    -1.5
    46.5
    20-10
    W
    W
    U
    49%
    52%
    57%
    55%
    74%
    56%
    6
    		Oct 12 at  Tampa Bay
    +164
    +3.5
    47.5
    19-30
    L
    L
    O
    40%
    27%
    51%
    46%
    87%
    75%
    5
    		Oct 2 at  LA Rams
    +350
    +7.5
    43.5
    26-23
    W
    W
    O
    20%
    16%
    43%
    43%
    60%
    50%
    4
    		Sep 28 VS  Jacksonville
    -180
    -3.5
    45.5
    21-26
    L
    L
    O
    57%
    78%
    25%
    54%
    60%
    35%
    3
    		Sep 21 VS  Arizona
    -122
    -1.5
    44.5
    16-15
    W
    L
    U
    52%
    61%
    64%
    58%
    69%
    64%
    2
    		Sep 14 at  New Orleans
    -166
    -3
    40.5
    26-21
    W
    W
    O
    66%
    80%
    69%
    72%
    53%
    46%
    1
    		Sep 7 at  Seattle
    -135
    -2.5
    43.5
    17-13
    W
    W
    U
    62%
    71%
    64%
    65%
    64%
    59%
    2025 Recent Results
    IndianapolisDraftKingsResultsMoney LineSpreadOVER Total
    WkDateOpponentMLLineOUScoreSUATSOUHandleBetsHandleBetsHandleBets
    15
    		Dec 14 at  Seattle
    +625
    +12.5
    41.5
    16-18
    L
    W
    U
    60%
    23%
    26%
    45%
    82%
    70%
    14
    		Dec 7 at  Jacksonville
    -135
    -2.5
    44.5
    19-36
    L
    L
    O
    65%
    55%
    55%
    54%
    40%
    62%
    13
    		Nov 30 VS  Houston
    -170
    -3
    44.5
    16-20
    L
    L
    U
    54%
    68%
    52%
    55%
    31%
    47%
    12
    		Nov 23 at  Kansas City
    +185
    +4.5
    50.5
    20-23
    L
    W
    U
    28%
    44%
    37%
    58%
    39%
    49%
    10
    		Nov 9 (n)  Atlanta
    -310
    -6.5
    48.5
    31-25
    W
    L
    O
    64%
    89%
    63%
    70%
    68%
    48%
    9
    		Nov 2 at  Pittsburgh
    -175
    -3
    51.5
    20-27
    L
    L
    U
    53%
    76%
    51%
    69%
    75%
    66%
    8
    		Oct 26 VS  Tennessee
    -1600
    -15.5
    47.5
    38-14
    W
    W
    O
    66%
    93%
    71%
    67%
    72%
    59%
    7
    		Oct 19 at  LA Chargers
    +120
    +2.5
    49.5
    38-24
    W
    W
    O
    32%
    60%
    44%
    57%
    76%
    66%
    6
    		Oct 12 VS  Arizona
    -455
    -8.5
    46.5
    31-27
    W
    L
    O
    80%
    91%
    68%
    67%
    64%
    62%
    5
    		Oct 5 VS  Las Vegas
    -360
    -7
    46.5
    40-6
    W
    W
    U
    79%
    92%
    67%
    65%
    84%
    60%
    4
    		Sep 28 at  LA Rams
    +154
    +3.5
    49.5
    20-27
    L
    L
    U
    39%
    32%
    57%
    51%
    77%
    64%
    3
    		Sep 21 at  Tennessee
    -250
    -6
    42.5
    41-20
    W
    W
    O
    83%
    90%
    62%
    62%
    51%
    70%
    2
    		Sep 14 VS  Denver
    +105
    +1.5
    43.5
    29-28
    W
    W
    O
    55%
    37%
    44%
    34%
    54%
    52%
    1
    		Sep 7 VS  Miami
    -112
    -1.5
    47.5
    33-8
    W
    W
    U
    52%
    30%
    36%
    30%
    47%
    41%
    Last 5 Head to Head Results
    DateRoad/HomeScoreLineMLOUSUATSF/DH/AOU
    2021
    Oct 24    		Indianapolis Colts Indianapolis Colts
    San Francisco 49ers San Francisco 49ers
    30
    18
    +3.5
    -3.5
    +165
    -190
    41.5
    IND
     
    IND
     
    DOG
    Road
     
    Over
    2017
    Oct 8    		San Francisco 49ers San Francisco 49ers
    Indianapolis Colts Indianapolis Colts
    23
    26
    +1
    -1
    +100
    -120
    44
    IND
     
    IND
     
    FAV
    HOME
     
    Over
    2013
    Sep 22    		Indianapolis Colts Indianapolis Colts
    San Francisco 49ers San Francisco 49ers
    27
    7
    +10.5
    -10.5
    +390
    -500
    45.5
    IND
     
    IND
     
    DOG
    Road
     
    Under
    2009
    Nov 1    		San Francisco 49ers San Francisco 49ers
    Indianapolis Colts Indianapolis Colts
    14
    18
    +12.5
    -12.5
    +575
    -725
    45
    IND
     
    SFO
     
    DOG
    Road
     
    Under
    2005
    Oct 9    		Indianapolis Colts Indianapolis Colts
    San Francisco 49ers San Francisco 49ers
    28
    3
    -16.5
    +16.5
    -
    -
    45.5
    IND
     
    IND
     
    FAV
    Road
     
    Under
       
    Statistic Breakdown
    Offensive Statistics
    SFO SFOStatisticIND INDEdgeMargin
    14
    		Games
    14
    		-
    0
    24.6
    		Points Scored
    28.0
    		IND IND
    3.4
    246.1
    		Passing Yards
    229.0
    		SFO SFO
    17.1
    10.4
    		PYPC
    10.8
    		IND IND
    0.3
    7.2
    		PYPA
    7.2
    		IND IND
    0.0
    68.8
    		Completion PCT
    67.0
    		SFO SFO
    1.8
    101.4
    		Rushing Yards
    128.5
    		IND IND
    27.1
    3.5
    		RYPA
    4.8
    		IND IND
    1.3
    37.8
    		PenaltyYards
    49.9
    		SFO SFO
    12.1
    1.4
    		Turnovers
    1.1
    		IND IND
    0.2
    Defensive Statistics
    SFO SFOStatisticIND INDEdgeMargin
    14
    		Games
    14
    		-
    0
    20.9
    		Points Scored
    21.6
    		SFO SFO
    0.7
    227.6
    		Passing Yards
    247.6
    		SFO SFO
    20.0
    9.7
    		PYPC
    10.4
    		SFO SFO
    0.8
    6.6
    		PYPA
    6.6
    		IND IND
    0.0
    68.8
    		Completion PCT
    63.4
    		IND IND
    5.4
    106.1
    		Rushing Yards
    95.1
    		IND IND
    10.9
    4.3
    		RYPA
    3.7
    		IND IND
    0.6
    44.6
    		PenaltyYards
    53.5
    		IND IND
    8.9
    1.0
    		Turnovers
    1.3
    		IND IND
    0.3
    Statistic Breakdown
    Offensive Statistics
    SFO SFOStatisticIND INDEdgeMargin
    8
    		Games
    6
    		SFO SFO
    2
    25.5
    		Points Scored
    31.2
    		IND IND
    5.7
    238.0
    		Passing Yards
    240.8
    		IND IND
    2.8
    10.3
    		PYPC
    11.8
    		IND IND
    1.5
    7.0
    		PYPA
    7.9
    		IND IND
    1.0
    67.5
    		Completion PCT
    67.2
    		SFO SFO
    0.3
    91.3
    		Rushing Yards
    136.5
    		IND IND
    45.3
    3.3
    		RYPA
    5.0
    		IND IND
    1.7
    37.5
    		PenaltyYards
    49.2
    		SFO SFO
    11.7
    0.9
    		Turnovers
    0.2
    		IND IND
    0.7
    Defensive Statistics
    SFO SFOStatisticIND INDEdgeMargin
    8
    		Games
    6
    		IND IND
    2
    20.9
    		Points Scored
    17.2
    		IND IND
    3.7
    252.8
    		Passing Yards
    220.8
    		IND IND
    31.9
    9.8
    		PYPC
    9.7
    		IND IND
    0.2
    7.2
    		PYPA
    6.2
    		IND IND
    1.0
    73.1
    		Completion PCT
    64.0
    		IND IND
    9.0
    104.4
    		Rushing Yards
    101.8
    		IND IND
    2.6
    4.2
    		RYPA
    4.2
    		SFO SFO
    0.1
    46.9
    		PenaltyYards
    57.8
    		IND IND
    11.0
    1.4
    		Turnovers
    1.5
    		IND IND
    0.1
    Statistic Breakdown
    Offensive Statistics
    SFO SFOStatisticIND INDEdgeMargin
    10
    		Games
    10
    		-
    0
    26.4
    		Points Scored
    26.9
    		IND IND
    0.5
    232.6
    		Passing Yards
    216.2
    		SFO SFO
    16.4
    10.2
    		PYPC
    10.3
    		IND IND
    0.1
    7.1
    		PYPA
    6.7
    		SFO SFO
    0.4
    70.0
    		Completion PCT
    65.1
    		SFO SFO
    4.9
    106.7
    		Rushing Yards
    125.4
    		IND IND
    18.7
    3.6
    		RYPA
    5.0
    		IND IND
    1.4
    30.5
    		PenaltyYards
    47.5
    		SFO SFO
    17.0
    1.1
    		Turnovers
    1.3
    		SFO SFO
    0.2
    Defensive Statistics
    SFO SFOStatisticIND INDEdgeMargin
    10
    		Games
    10
    		-
    0
    21.8
    		Points Scored
    22.0
    		SFO SFO
    0.2
    252.6
    		Passing Yards
    257.1
    		SFO SFO
    4.5
    10.3
    		PYPC
    10.8
    		SFO SFO
    0.5
    7.1
    		PYPA
    6.7
    		IND IND
    0.4
    68.9
    		Completion PCT
    62.2
    		IND IND
    6.7
    102.3
    		Rushing Yards
    94.8
    		IND IND
    7.5
    4.5
    		RYPA
    3.5
    		IND IND
    1.0
    43.0
    		PenaltyYards
    52.0
    		IND IND
    9.0
    1.1
    		Turnovers
    1.2
    		IND IND
    0.1
    Statistic Breakdown
    Offensive Statistics
    SFO SFOStatisticIND INDEdgeMargin
    6
    		Games
    6
    		-
    0
    17.5
    		Points Scored
    25.0
    		IND IND
    7.5
    173.2
    		Passing Yards
    257.5
    		IND IND
    84.3
    10.4
    		PYPC
    10.9
    		IND IND
    0.5
    5.9
    		PYPA
    7.1
    		IND IND
    1.3
    56.5
    		Completion PCT
    65.4
    		IND IND
    8.9
    118.2
    		Rushing Yards
    133.2
    		IND IND
    15.0
    5.1
    		RYPA
    4.2
    		SFO SFO
    0.9
    65.8
    		PenaltyYards
    52.5
    		IND IND
    13.3
    2.3
    		Turnovers
    1.8
    		IND IND
    0.5
     49ers
    PlayerPosInjury
    Ricky Pearsall
    WR
    		Ankle - is Questionable Sunday vs Chicago
    George Kittle
    TE
    		Ankle - left last game, is probable Sunday vs Chicago
    Renardo Green
    CB
    		Neck - is Questionable Sunday vs Chicago
    Chase Lucas
    CB
    		Undisclosed - is OUT Monday vs Indianapolis
    Curtis Robinson
    LB
    		Undisclosed - is OUT Monday vs Indianapolis
    Kevin Givens
    DL
    		Undisclosed - is OUT Monday vs Indianapolis
    Robert Beal
    LB
    		Undisclosed - is OUT Monday vs Indianapolis
    Isaac Guerendo
    RB
    		Undisclosed - is OUT Monday vs Indianapolis
    Yetur Gross-Matos
    DL
    		Hamstring - is upgraded to probable Monday vs Indianapolis
    Jordan Elliott
    DL
    		Knee - is upgraded to probable Monday vs Indianapolis
    Spencer Burford
    G
    		Knee - is upgraded to probable Monday vs Indianapolis
    Tatum Bethune
    LB
    		Ankle - is upgraded to probable Monday vs Indianapolis
    Sam Okuayinonu
    DL
    		Ankle - is upgraded to probable Monday vs Indianapolis
    Nick Martin
    LB
    		Concussion - IR
    Brandon Aiyuk
    WR
    		Knee - IR; is out for season
    Christian McCaffrey
    RB
    		Back - is upgraded to probable Sunday vs Tennessee
    Eddy Pineiro
    K
    		Hamstring - is upgraded to probable Sunday vs Tennessee
    Mykel Williams
    DL
    		Knee - is out for season
    Fred Warner
    LB
    		Ankle - IR; is out for season
    Kurtis Rourke
    QB
    		Knee - IR
    Jacob Cowing
    WR
    		Hamstring - IR
    Nick Bosa
    DE
    		ACL - IR; is out for season
    Patrick Taylor Jr
    RB
    		Shoulder - is out for season
     Colts
    PlayerPositionInjury
    Dalton Tucker
    G
    		Shoulder - left last game, is Questionable Sunday vs Jacksonville
    JT Tuimoloau
    DE
    		Oblique - left last game, is Questionable Sunday vs Jacksonville
    Anthony Richardson
    QB
    		Eye - is Questionable Sunday vs Jacksonville
    Bernhard Raimann
    T
    		Elbow - is Questionable Sunday vs Jacksonville
    Anthony Gould
    WR
    		Foot - is Questionable Sunday vs Jacksonville
    Tanor Bortolini
    G
    		Concussion - left last game, is Questionable Sunday vs Jacksonville
    Will Mallory
    TE
    		Undisclosed - is OUT Monday vs San Francisco
    Reuben Lowery
    CB
    		Undisclosed - is OUT Monday vs San Francisco
    DJ Giddens
    RB
    		Undisclosed - is OUT Monday vs San Francisco
    Jaylon Carlies
    LB
    		Undisclosed - is OUT Monday vs San Francisco
    Alec Pierce
    WR
    		Achilles - is upgraded to probable Monday vs San Francisco
    Daniel Scott
    S
    		Knee - is probable Monday vs San Francisco
    DeForest Buckner
    DT
    		Neck - is probable Monday vs San Francisco
    Bernhard Raimann
    T
    		Elbow - is Questionable to return Sunday vs Seattle
    Braden Smith
    G
    		Neck - IR
    Tyquan Lewis
    DT
    		Ankle - is probable Sunday vs Seattle
    Philip Rivers
    QB
    		None - has been named the starter Sunday vs Seattle
    Riley Leonard
    QB
    		Knee - is upgraded to probable Sunday vs Seattle
    Charvarius Ward
    CB
    		Concussion - IR
    Chris Lammons
    DB
    		Foot - IR
    Daniel Jones
    QB
    		Achilles - IR
    Sauce Gardner
    CB
    		Calf - is out indefinitely
    Ashton Dulin
    WR
    		Hamstring - IR
    Hunter Wohler
    S
    		Foot - IR
    Jacob Phillips
    LB
    		Biceps - IR
    Jack Wilson
    -
    		Undisclosed - IR
    Blake Freeland
    -
    		Leg - IR
    DJ Montgomery
    WR
    		Undisclosed - IR
    Salvon Ahmed
    RB
    		Ankle - IR
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