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| Time/TV | Thursday September 4, 2025 | Line | Money Line | OU | Location |
|---|---|---|---|---|---|
8:20 PM ET NBC |  Dallas Cowboys Philadelphia Eagles | +7 -7 | +270 -340 | 46.5 | Lincoln Financial Field philadelphia , PA |
| Time/TV | Friday September 5, 2025 | Line | Money Line | OU | Location |
8:00 PM ET YouTube |  Kansas City Chiefs Los Angeles Chargers | -3 +3 | -155 +130 | 45.5 | SoFi Stadium los angeles , CA |
| Time/TV | Sunday September 7, 2025 | Line | Money Line | OU | Location |
1:00 PM ET CBS |  Las Vegas Raiders New England Patriots | +3 -3 | +140 -166 | 42.5 | Gillette Stadium foxboro , MA |
1:00 PM ET CBS |  Pittsburgh Steelers New York Jets | -3 +3 | -162 +136 | 39.5 | Metlife Stadium east rutherford , NJ |
1:00 PM ET FOX |  Cincinnati Bengals Cleveland Browns | -5.5 +5.5 | -238 +195 | 44.5 | Cleveland Browns Stadium cleveland , OH |
1:00 PM ET CBS |  Miami Dolphins Indianapolis Colts | +1.5 -1.5 | -108 -112 | 45.5 | Lucas Oil Stadium indianapolis , IN |
1:00 PM ET FOX |  Carolina Panthers Jacksonville Jaguars | +3 -3 | +136 -162 | 45.5 | EverBank Stadium jacksonville , FL |
1:00 PM ET FOX |  New York Giants Wash Commanders | +7 -7 | +235 -290 | 45.5 | Northwest Stadium landover , MD |
1:00 PM ET FOX |  Tampa Bay Buccaneers Atlanta Falcons | -2.5 +2.5 | -130 +110 | 48.5 | Mercedes-Benz Stadium atlanta , GA |
1:00 PM ET CBS |  Arizona Cardinals New Orleans Saints | -5.5 +5.5 | -245 +200 | 42.5 | Caesars Superdome new orleans , LA |
4:05 PM ET FOX |  Tennessee Titans Denver Broncos | +7.5 -7.5 | +310 -395 | 41.5 | Empower Field At Mile High denver , CO |
4:05 PM ET FOX |  San Francisco 49ers Seattle Seahawks | -1.5 +1.5 | -122 +102 | 45.5 | Lumen Field seattle , WA |
4:25 PM ET CBS |  Detroit Lions Green Bay Packers | +1.5 -1.5 | +102 -122 | 48.5 | Lambeau Field green bay , WI |
4:25 PM ET CBS |  Houston Texans Los Angeles Rams | +3 -3 | +136 -162 | 45.5 | SoFi Stadium los angeles , CA |
8:20 PM ET NBC |  Baltimore Ravens Buffalo Bills | +1.5 -1.5 | +102 -122 | 51.5 | Highmark Stadium buffalo , NY |
| Time/TV | Monday September 8, 2025 | Line | Money Line | OU | Location |
8:15 PM ET ABC |  Minnesota Vikings Chicago Bears | +1.5 -1.5 | +100 -120 | 44.5 | Soldier Field chicago , IL |
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