| Mitch Wishnowsky | P | Back - is Questionable Sunday vs Buffalo |
| Charvarius Ward | CB | Personal - is Questionable Sunday vs Buffalo |
| Brock Purdy | QB | Shoulder - is Questionable Sunday vs Buffalo |
| Kevin Givens | DL | Groin - is Questionable Sunday vs Buffalo |
| Jacob Cowing | WR | Concussion - is Questionable Sunday vs Buffalo |
| Nick Bosa | DE | Hip - is Questionable Sunday vs Buffalo |
| Tatum Bethune | LB | Knee - is Questionable Sunday vs Buffalo |
| Trent Williams | T | Ankle - is upgraded to probable Sunday vs Green Bay |
| Brandon Allen | QB | None - has been named the starter Sunday vs Green Bay |
| Darrell Luter Jr | CB | Pelvis - IR |
| George Kittle | TE | Hamstring - is upgraded to probable Sunday vs Green Bay |
| Aaron Banks | OL | Thigh - is upgraded to probable Sunday vs Seattle |
| Jon Feliciano | OL | Knee - is upgraded to probable Sunday vs Seattle |
| Trent Williams | T | Ankle - is upgraded to probable Sunday vs Seattle |
| Nick Bosa | DE | Hip - is upgraded to probable Sunday vs Seattle |
| Yetur Gross-Matos | DL | Knee - is upgraded to probable Sunday vs Seattle |
| Chris Conley | WR | Hamstring - is upgraded to probable Sunday vs Seattle |
| Brandon Aiyuk | WR | ACL - IR; is out for season |
| Matthew Wright | K | Shoulder - IR |
| Talanoa Hufanga | S | Wrist - IR |
| Jake Moody | K | Ankle - is out indefinitely |
| Curtis Robinson | LB | ACL - is out for season |
| Javon Hargrave | DL | Triceps - is out for season |
| Drake Jackson | DL | Knee - PUP |
| Tayler Hawkins | S | Undisclosed - IR |
| Dre Greenlaw | LB | Achilles - PUP |
| Elijah Mitchell | RB | Hamstring - IR |
| Ambry Thomas | CB | Undisclosed - IR |
Active Betting Splits
