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Highmark Stadium

FINAL	Score	Line	OU	Record	ATS	O-U-P	PF	PA	EST Score	EST Line
49ers	10	+6.5		5-6	4-7-0	6-5-0	23.6	23.6	22.5	47.7
Bills	35	-6.5	45.5	9-2	7-4-0	7-4-0	29.1	19.5	25.2	-2.6

DraftKings Circa Sports

DraftKings Betting Splits

Sunday,Dec 1	Spread	Handle	Bets	Total	Handle	Bets	Money	Handle	Bets
San Francisco 49ers Buffalo Bills	+6.5 -6.5	32% 68%	23% 77%	45.5 45.5	52% 48%	47% 53%	+275 -345	29% 71%	12% 88%

Circa Sports Betting Splits

Sunday,Dec 1	Spread	Handle	Bets	Total	Handle	Bets	Money	Handle	Bets
San Francisco 49ers Buffalo Bills	+6.5 -6.5	52% 48%	28% 72%	46 46	60% 40%	48% 52%	256 -300	67% 33%	63% 37%

Pro Picks at a Glance

VSiN Expert	Sport	Event Date	Selection	Score	Result
Rich Gannon	NFL	2024-12-01	Bills (-7) vs 49ers	35 - 10	WIN
Dustin Swedelson	NFL	2024-12-01	Christian Mccaffrey (49ers) OVER 30.5 Receiving Yards (-110)	14	LOSS
Wes Reynolds	NFL	2024-12-01	49ers at Bills [LIVE] - OVER (42.5)	45	WIN
Adam Schein	NFL	2024-12-01	Bills (-7) vs 49ers	35 - 10	WIN
Matt Brown	NFL	2024-12-01	49ers (-6.5) at Bills	10 - 35	LOSS
Steve Fezzik	NFL	2024-12-01	49ers (+7) at Bills	10 - 35	LOSS
Steve Fezzik	NFL	2024-12-01	49ers at Bills - OVER (43.5)	45	WIN
Chris Macero	NFL	2024-12-01	49ers (+7) at Bills	10 - 35	LOSS
Randy McKay	NFL	2024-12-01	49ers (+7) at Bills	10 - 35	LOSS
Scott Pritchard	NFL	2024-12-01	49ers (+7) at Bills	10 - 35	LOSS
Scott Pritchard	NFL	2024-12-01	49ers at Bills - OVER (43.5)	45	WIN
Weston Stradtman	NFL	2024-12-01	49ers (+7) at Bills	10 - 35	LOSS
James Salinas	NFL	2024-12-01	49ers (+7) at Bills	10 - 35	LOSS
Sean Green	NFL	2024-12-01	Money Line - 49ers (+205) at Bills	10 - 35	LOSS
CJ Sullivan	NFL	2024-12-01	49ers at Bills - UNDER (44)	45	LOSS
Wes Reynolds	NFL	2024-12-01	49ers (+7) at Bills	10 - 35	LOSS
Mitch Moss	NFL	2024-12-01	Bills (-3.5) vs 49ers	35 - 10	WIN
Michael Lombardi	NFL	2024-12-01	Bills (-7) vs 49ers	35 - 10	WIN

Makinen Weekly Ratings

Sunday, December 1	Score	Line	OU	PR	Line	Score	Proj	Score	Proj
		DraftKings			Power Ratings		Effective Strength		Bettor Rating
San Francisco 49ers	10	+6.5		26.5		22.5	47.7	19.8	46.6
Buffalo Bills	35	-6.5	45.5	30.0	-10.6	25.2	-2.6	26.9	-7.1

San Francisco 49ers Buffalo Bills Head to Head

2024 Recent Results

Wk	Date	Opponent	ML	Line	OU	Score	SU	ATS	OU	Handle	Bets	Handle	Bets	Handle	Bets
San Francisco			DraftKings			Results				Money Line		Spread		OVER Total
12	Nov 24	at Green Bay	+235	+6.5	44.5	10-38	L	L	O	40%	37%	36%	44%	57%	60%
11	Nov 17	VS Seattle	-265	-6	48.5	17-20	L	L	U	86%	91%	71%	74%	20%	55%
10	Nov 10	at Tampa Bay	-298	-6.5	50.5	23-20	W	L	U	75%	79%	61%	60%	66%	65%
8	Oct 27	VS Dallas	-238	-5.5	47.5	30-24	W	W	O	48%	70%	49%	55%	52%	62%
7	Oct 20	VS Kansas City	-142	-2.5	48	18-28	L	L	U	48%	32%	52%	39%	74%	67%
6	Oct 10	at Seattle	-198	-4	49	36-24	W	W	O	66%	66%	59%	61%	53%	49%
5	Oct 6	VS Arizona	-340	-7.5	49	23-24	L	L	U	74%	88%	47%	50%	77%	65%
4	Sep 29	VS New England	-575	-10.5	42.5	30-13	W	W	O	71%	91%	50%	50%	34%	44%
3	Sep 22	at LA Rams	-258	-6	44.5	24-27	L	L	O	80%	87%	64%	64%	33%	48%
2	Sep 15	at Minnesota	-218	-4.5	46.5	17-23	L	L	U	87%	93%	75%	85%	62%	64%
1	Sep 9	VS NY Jets	-192	-3.5	43	32-19	W	W	O	48%	67%	48%	57%	67%	56%

2024 Recent Results

Wk	Date	Opponent	ML	Line	OU	Score	SU	ATS	OU	Handle	Bets	Handle	Bets	Handle	Bets
Buffalo			DraftKings			Results				Money Line		Spread		OVER Total
11	Nov 17	VS Kansas City	-148	-2.5	47	30-21	W	W	O	54%	39%	65%	48%	75%	74%
10	Nov 10	at Indianapolis	-230	-4.5	46.5	30-20	W	W	O	89%	92%	63%	81%	81%	66%
9	Nov 3	VS Miami	-290	-6.5	49.5	30-27	W	L	O	76%	87%	70%	72%	72%	70%
8	Oct 27	at Seattle	-170	-3	45.5	31-10	W	W	U	80%	80%	76%	77%	72%	81%
7	Oct 20	VS Tennessee	-535	-9.5	41	34-10	W	W	O	90%	96%	71%	75%	79%	79%
6	Oct 14	at NY Jets	-120	-1	42.5	23-20	W	W	O	48%	65%	67%	77%	60%	67%
5	Oct 6	at Houston	+102	+1.5	48	20-23	L	L	U	58%	64%	58%	66%	75%	81%
4	Sep 29	at Baltimore	+114	+2.5	47.5	10-35	L	L	U	45%	57%	45%	58%	76%	76%
3	Sep 23	VS Jacksonville	-225	-4.5	46.5	47-10	W	W	O	58%	81%	67%	77%	55%	59%
2	Sep 12	at Miami	+114	+2.5	49	31-10	W	W	U	54%	58%	42%	45%	74%	75%
1	Sep 8	VS Arizona	-325	-6.5	46	34-28	W	L	O	62%	86%	54%	61%	77%	63%

Last 5 Head to Head Results

Date	Road/Home	Score	Line	ML	OU	SU	ATS	F/D	H/A	OU
2020 Dec 7	San Francisco 49ers Buffalo Bills	24 34	+2.5 -2.5	+119 -	48	BUF	BUF	FAV		Over
2016 Oct 16	San Francisco 49ers Buffalo Bills	16 45	+7.5 -7.5	+280 -345	44	BUF	BUF	FAV	HOME	Over
2012 Oct 7	Buffalo Bills San Francisco 49ers	3 45	+10 -10	+395 -475	45.5	SFO	SFO	FAV	Home	Over
2008 Nov 30	San Francisco 49ers Buffalo Bills	10 3	+6.5 -6.5	+270 -290	43	SFO	SFO	DOG	Road	Under
2004 Dec 26	Buffalo Bills San Francisco 49ers	41 7	-11 +11	- -	42.5	BUF	BUF	FAV	Road	Over

All Games 2024 2024 Home/Road Games Last 10 Games Head to Head

Statistic Breakdown

Offensive Statistics

SFO	Statistic	BUF	Edge	Margin
11	Games	11	-	0
23.6	Points Scored	29.1	BUF	5.5
246.2	Passing Yards	226.1	SFO	20.1
12.4	PYPC	11.4	SFO	1.0
8.1	PYPA	7.3	SFO	0.8
65.4	Completion PCT	64.0	SFO	1.3
138.4	Rushing Yards	119.2	SFO	19.2
4.9	RYPA	4.3	SFO	0.6
52.0	PenaltyYards	47.0	BUF	5.0
1.5	Turnovers	0.6	BUF	0.8

Defensive Statistics

SFO	Statistic	BUF	Edge	Margin
11	Games	11	-	0
23.6	Points Scored	19.5	BUF	4.2
193.5	Passing Yards	210.0	SFO	16.6
9.8	PYPC	9.0	BUF	0.8
6.2	PYPA	6.2	-	0.0
63.1	Completion PCT	68.9	SFO	5.8
110.8	Rushing Yards	119.1	SFO	8.3
4.2	RYPA	4.9	SFO	0.6
37.5	PenaltyYards	59.4	BUF	21.9
1.5	Turnovers	1.9	BUF	0.5

Statistic Breakdown

Offensive Statistics

SFO	Statistic	BUF	Edge	Margin
5	Games	5	-	0
22.0	Points Scored	35.0	BUF	13.0
274.4	Passing Yards	259.2	SFO	15.2
12.5	PYPC	11.3	SFO	1.2
8.6	PYPA	7.8	SFO	0.8
69.2	Completion PCT	69.3	BUF	0.1
117.2	Rushing Yards	104.8	SFO	12.4
4.5	RYPA	4.0	SFO	0.5
60.2	PenaltyYards	43.2	BUF	17.0
1.4	Turnovers	0.6	BUF	0.8

Defensive Statistics

SFO	Statistic	BUF	Edge	Margin
5	Games	5	-	0
26.4	Points Scored	19.2	BUF	7.2
204.4	Passing Yards	179.6	BUF	24.8
10.9	PYPC	7.5	BUF	3.4
6.6	PYPA	5.0	BUF	1.5
60.3	Completion PCT	67.4	SFO	7.2
115.0	Rushing Yards	106.4	BUF	8.6
4.1	RYPA	4.7	SFO	0.5
55.8	PenaltyYards	48.4	SFO	7.4
1.0	Turnovers	1.6	BUF	0.6

Statistic Breakdown

Offensive Statistics

SFO	Statistic	BUF	Edge	Margin
10	Games	10	-	0
22.8	Points Scored	28.6	BUF	5.8
248.7	Passing Yards	226.5	SFO	22.2
12.4	PYPC	11.3	SFO	1.2
8.1	PYPA	7.1	SFO	1.0
65.4	Completion PCT	63.0	SFO	2.4
134.2	Rushing Yards	118.1	SFO	16.1
4.9	RYPA	4.3	SFO	0.6
53.2	PenaltyYards	45.2	BUF	8.0
1.6	Turnovers	0.6	BUF	1.0

Defensive Statistics

SFO	Statistic	BUF	Edge	Margin
10	Games	10	-	0
24.1	Points Scored	18.6	BUF	5.5
193.0	Passing Yards	216.4	SFO	23.4
9.8	PYPC	9.2	BUF	0.6
6.1	PYPA	6.3	SFO	0.2
62.9	Completion PCT	69.0	SFO	6.2
115.1	Rushing Yards	118.6	SFO	3.5
4.3	RYPA	4.8	SFO	0.6
40.2	PenaltyYards	62.2	BUF	22.0
1.4	Turnovers	2.0	BUF	0.6

Statistic Breakdown

Offensive Statistics

SFO	Statistic	BUF	Edge	Margin
6	Games	6	-	0
22.8	Points Scored	21.0	SFO	1.8
199.3	Passing Yards	205.5	BUF	6.2
12.0	PYPC	9.6	SFO	2.4
7.3	PYPA	6.0	SFO	1.3
61.4	Completion PCT	62.9	BUF	1.6
153.3	Rushing Yards	149.0	SFO	4.3
4.9	RYPA	5.5	BUF	0.6
37.2	PenaltyYards	47.8	SFO	10.7
1.5	Turnovers	2.0	SFO	0.5

Circa Football Invitational

All Games	Sport	Event Date	Selection	BB	Score	Result
Weston Stradtman (2)	NFL	2024-12-01	49ers (+7) at Bills		10 - 35	LOSS
Chris Macero (5)	NFL	2024-12-01	49ers (+7) at Bills		10 - 35	LOSS
James Salinas (8)	NFL	2024-12-01	49ers (+7) at Bills		10 - 35	LOSS
Scott Pritchard (9)	NFL	2024-12-01	49ers (+7) at Bills		10 - 35	LOSS
Randy McKay (15)	NFL	2024-12-01	49ers (+7) at Bills		10 - 35	LOSS
Steve Fezzik (15)	NFL	2024-12-01	49ers (+7) at Bills		10 - 35	LOSS
All Games	Sport	Event Date	Selection	BB	Score	Result
Scott Pritchard (9)	NFL	2024-12-01	49ers at Bills - OVER (43.5)		45	WIN
Steve Fezzik (15)	NFL	2024-12-01	49ers at Bills - OVER (43.5)		45	WIN

Player	Pos	Injury
49ers
Brock Purdy	QB	Shoulder - is Questionable Sunday vs Buffalo
Demetrius Flannigan-Fowles	LB	Knee - left last game, is Questionable Sunday vs Buffalo
Mitch Wishnowsky	P	Back - is Questionable Sunday vs Buffalo
Charvarius Ward	CB	Personal - is Questionable Sunday vs Buffalo
Kevin Givens	DL	Groin - is Questionable Sunday vs Buffalo
Jacob Cowing	WR	Concussion - is Questionable Sunday vs Buffalo
Nick Bosa	DE	Hip - is Questionable Sunday vs Buffalo
Tatum Bethune	LB	Knee - is Questionable Sunday vs Buffalo
Darrell Luter Jr	CB	Pelvis - IR
Brandon Aiyuk	WR	ACL - IR; is out for season
Matthew Wright	K	Shoulder - IR
Talanoa Hufanga	S	Wrist - IR
Jake Moody	K	Ankle - is out indefinitely
Curtis Robinson	LB	ACL - is out for season
Javon Hargrave	DL	Triceps - is out for season
Drake Jackson	DL	Knee - PUP
Tayler Hawkins	S	Undisclosed - IR
Dre Greenlaw	LB	Achilles - PUP
Elijah Mitchell	RB	Hamstring - IR
Ambry Thomas	CB	Undisclosed - IR

Player	Position	Injury
Bills
Dalton Kincaid	TE	Knee - is Questionable Sunday vs San Francisco
Keon Coleman	WR	Wrist - is Questionable Sunday vs San Francisco
Spencer Brown	T	Undisclosed - is Questionable Sunday vs San Francisco
Dawuane Smoot	DE	Wrist - IR
DeWayne Carter	DT	Wrist - IR
Tylan Grable	OL	Groin - IR
Shane Buechele	QB	Neck - IR
Terrell Burgess	S	Hamstring - IR
Dee Delaney	DB	Knee - IR
Darrynton Evans	RB	Hamstring - IR
Travis Clayton	T	Shoulder - IR
Matt Milano	LB	Biceps - IR

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