Highmark Stadium

    8:20 PM ET (NBC)
    ScoreLineOURecordATSO-U-PPFPAEST ScoreEST Line
     49ers
    0
    -2
    3-43-4-04-3-025.722.6
    0
    0
     Bills
    0
    +2
    47
    5-24-3-04-3-028.419.4
    0
    0

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    2024 Recent Results
    San FranciscoDraftKingsResultsMoney LineSpreadOVER Total
    WkDateOpponentMLLineOUScoreSUATSOUHandleBetsHandleBetsHandleBets
    Oct 20 VS  Kansas City
    -142
    -2.5
    48
    18-28
    L
    L
    U
    48%
    32%
    52%
    39%
    74%
    67%
    Oct 10 at  Seattle
    -198
    -4
    49
    36-24
    W
    W
    O
    66%
    66%
    59%
    61%
    53%
    49%
    Oct 6 VS  Arizona
    -340
    -7.5
    49
    23-24
    L
    L
    U
    74%
    88%
    47%
    50%
    77%
    65%
    Sep 29 VS  New England
    -575
    -10.5
    42.5
    30-13
    W
    W
    O
    71%
    91%
    50%
    50%
    34%
    44%
    Sep 22 at  LA Rams
    -258
    -6
    44.5
    24-27
    L
    L
    O
    80%
    87%
    64%
    64%
    33%
    48%
    Sep 15 at  Minnesota
    -218
    -4.5
    46.5
    17-23
    L
    L
    U
    87%
    93%
    75%
    85%
    62%
    64%
    Sep 9 VS  NY Jets
    -192
    -3.5
    43
    32-19
    W
    W
    O
    48%
    67%
    48%
    57%
    67%
    56%

    2024 Recent Results
    BuffaloDraftKingsResultsMoney LineSpreadOVER Total
    WkDateOpponentMLLineOUScoreSUATSOUHandleBetsHandleBetsHandleBets
    Oct 20 VS  Tennessee
    -535
    -9.5
    41
    34-10
    W
    W
    O
    90%
    96%
    71%
    75%
    79%
    79%
    Oct 14 at  NY Jets
    -120
    -1
    42.5
    23-20
    W
    W
    O
    48%
    65%
    67%
    77%
    60%
    67%
    Oct 6 at  Houston
    +102
    +1.5
    48
    20-23
    L
    L
    U
    58%
    64%
    58%
    66%
    75%
    81%
    Sep 29 at  Baltimore
    +114
    +2.5
    47.5
    10-35
    L
    L
    U
    45%
    57%
    45%
    58%
    76%
    76%
    Sep 23 VS  Jacksonville
    -225
    -4.5
    46.5
    47-10
    W
    W
    O
    58%
    81%
    67%
    77%
    55%
    59%
    Sep 12 at  Miami
    +114
    +2.5
    49
    31-10
    W
    W
    U
    54%
    58%
    42%
    45%
    74%
    75%
    Sep 8 VS  Arizona
    -325
    -6.5
    46
    34-28
    W
    L
    O
    62%
    86%
    54%
    61%
    77%
    63%

    Last 5 Head to Head Results
    DateRoad/HomeScoreLineMLOUSUATSF/DH/AOU

    2020
    Dec 7
    San Francisco 49ers San Francisco 49ers
    Buffalo Bills Buffalo Bills
    24


    34
    +2.5


    -2.5
    +119


    -
    48
    BUF

     
    BUF

     
    FAV

    Over

    2016
    Oct 16
    San Francisco 49ers San Francisco 49ers
    Buffalo Bills Buffalo Bills
    16


    45
    +7.5


    -7.5
    +280


    -345
    44
    BUF

     
    BUF

     
    FAV
    HOME

     
    Over

    2012
    Oct 7
    Buffalo Bills Buffalo Bills
    San Francisco 49ers San Francisco 49ers
    3


    45
    +10


    -10
    +395


    -475
    45.5
    SFO

     
    SFO

     
    FAV
    Home

     
    Over

    2008
    Nov 30
    San Francisco 49ers San Francisco 49ers
    Buffalo Bills Buffalo Bills
    10


    3
    +6.5


    -6.5
    +270


    -290
    43
    SFO

     
    SFO

     
    DOG
    Road

     
    Under

    2004
    Dec 26
    Buffalo Bills Buffalo Bills
    San Francisco 49ers San Francisco 49ers
    41


    7
    -11


    +11
    -


    -
    42.5
    BUF

     
    BUF

     
    FAV
    Road

     
    Over



    Statistic Breakdown
    Offensive Statistics
    SFO SFOStatisticBUF BUFEdgeMargin
    7
    Games
    7
    -
    0
    25.7
    Points Scored
    28.4
    BUF BUF
    2.7
    254.4
    Passing Yards
    204.7
    SFO SFO
    49.7
    12.9
    PYPC
    11.8
    SFO SFO
    1.1
    8.3
    PYPA
    7.5
    SFO SFO
    0.8
    63.9
    Completion PCT
    63.0
    SFO SFO
    0.9
    149.9
    Rushing Yards
    116.3
    SFO SFO
    33.6
    5.0
    RYPA
    4.2
    SFO SFO
    0.7
    45.6
    PenaltyYards
    44.9
    BUF BUF
    0.7
    1.6
    Turnovers
    0.3
    BUF BUF
    1.3
    Defensive Statistics
    SFO SFOStatisticBUF BUFEdgeMargin
    7
    Games
    7
    -
    0
    22.6
    Points Scored
    19.4
    BUF BUF
    3.1
    205.1
    Passing Yards
    209.1
    SFO SFO
    4.0
    10.6
    PYPC
    9.0
    BUF BUF
    1.5
    6.5
    PYPA
    5.9
    BUF BUF
    0.6
    61.3
    Completion PCT
    65.3
    SFO SFO
    4.1
    112.9
    Rushing Yards
    132.9
    SFO SFO
    20.0
    4.4
    RYPA
    5.1
    SFO SFO
    0.6
    40.0
    PenaltyYards
    61.7
    BUF BUF
    21.7
    1.9
    Turnovers
    1.7
    SFO SFO
    0.2

    Statistic Breakdown
    Offensive Statistics
    SFO SFOStatisticBUF BUFEdgeMargin
    3
    Games
    3
    -
    0
    25.7
    Points Scored
    38.3
    BUF BUF
    12.7
    279.0
    Passing Yards
    267.7
    SFO SFO
    11.3
    12.3
    PYPC
    12.8
    BUF BUF
    0.4
    8.9
    PYPA
    9.2
    BUF BUF
    0.3
    72.3
    Completion PCT
    72.4
    BUF BUF
    0.1
    155.7
    Rushing Yards
    108.7
    SFO SFO
    47.0
    5.1
    RYPA
    4.0
    SFO SFO
    1.1
    58.3
    PenaltyYards
    50.7
    BUF BUF
    7.7
    1.0
    Turnovers
    0.3
    BUF BUF
    0.7
    Defensive Statistics
    SFO SFOStatisticBUF BUFEdgeMargin
    3
    Games
    3
    -
    0
    24.7
    Points Scored
    16.0
    BUF BUF
    8.7
    253.7
    Passing Yards
    164.3
    BUF BUF
    89.3
    12.1
    PYPC
    6.9
    BUF BUF
    5.2
    7.3
    PYPA
    4.2
    BUF BUF
    3.1
    60.6
    Completion PCT
    61.5
    SFO SFO
    1.0
    98.7
    Rushing Yards
    101.7
    SFO SFO
    3.0
    4.2
    RYPA
    4.6
    SFO SFO
    0.4
    65.7
    PenaltyYards
    42.7
    SFO SFO
    23.0
    1.7
    Turnovers
    1.7
    -
    0.0

    Statistic Breakdown
    Offensive Statistics
    SFO SFOStatisticBUF BUFEdgeMargin
    10
    Games
    10
    -
    0
    26.0
    Points Scored
    27.5
    BUF BUF
    1.5
    255.6
    Passing Yards
    215.3
    SFO SFO
    40.3
    12.5
    PYPC
    10.9
    SFO SFO
    1.6
    7.9
    PYPA
    7.2
    SFO SFO
    0.7
    63.1
    Completion PCT
    66.2
    BUF BUF
    3.1
    142.5
    Rushing Yards
    130.3
    SFO SFO
    12.2
    4.8
    RYPA
    4.3
    SFO SFO
    0.4
    46.2
    PenaltyYards
    40.7
    BUF BUF
    5.5
    1.4
    Turnovers
    0.5
    BUF BUF
    0.9
    Defensive Statistics
    SFO SFOStatisticBUF BUFEdgeMargin
    10
    Games
    10
    -
    0
    23.5
    Points Scored
    19.4
    BUF BUF
    4.1
    221.5
    Passing Yards
    206.4
    BUF BUF
    15.1
    10.3
    PYPC
    9.5
    BUF BUF
    0.8
    6.5
    PYPA
    6.1
    BUF BUF
    0.3
    63.0
    Completion PCT
    64.7
    SFO SFO
    1.7
    123.8
    Rushing Yards
    129.0
    SFO SFO
    5.2
    4.7
    RYPA
    5.2
    SFO SFO
    0.5
    35.5
    PenaltyYards
    52.6
    BUF BUF
    17.1
    1.8
    Turnovers
    1.7
    SFO SFO
    0.1

    Statistic Breakdown
    Offensive Statistics
    SFO SFOStatisticBUF BUFEdgeMargin
    6
    Games
    6
    -
    0
    22.8
    Points Scored
    21.0
    SFO SFO
    1.8
    199.3
    Passing Yards
    205.5
    BUF BUF
    6.2
    12.0
    PYPC
    9.6
    SFO SFO
    2.4
    7.3
    PYPA
    6.0
    SFO SFO
    1.3
    61.4
    Completion PCT
    62.9
    BUF BUF
    1.6
    153.3
    Rushing Yards
    149.0
    SFO SFO
    4.3
    4.9
    RYPA
    5.5
    BUF BUF
    0.6
    37.2
    PenaltyYards
    47.8
    SFO SFO
    10.7
    1.5
    Turnovers
    2.0
    SFO SFO
    0.5