Highmark Stadium

    8:20 PM ET (NBC)
    ScoreLineOURecordATSO-U-PPFPAEST ScoreEST Line
     49ers
    0
    -2
    3-43-4-04-3-025.722.6
    0
    0
     Bills
    0
    +2
    47
    5-24-3-04-3-028.419.4
    0
    0


    Head to Head Results
    DateRoad/HomeScoreLineMLOUSUATSF/DH/AOU

    2020
    Dec 7
    San Francisco 49ers San Francisco 49ers
    Buffalo Bills Buffalo Bills
    24


    34
    +2.5


    -2.5
    +119


    -
    48
    BUF

     
    BUF

     
    FAV

    Over

    2016
    Oct 16
    San Francisco 49ers San Francisco 49ers
    Buffalo Bills Buffalo Bills
    16


    45
    +7.5


    -7.5
    +280


    -345
    44
    BUF

     
    BUF

     
    FAV
    HOME

     
    Over

    2012
    Oct 7
    Buffalo Bills Buffalo Bills
    San Francisco 49ers San Francisco 49ers
    3


    45
    +10


    -10
    +395


    -475
    45.5
    SFO

     
    SFO

     
    FAV
    Home

     
    Over

    2008
    Nov 30
    San Francisco 49ers San Francisco 49ers
    Buffalo Bills Buffalo Bills
    10


    3
    +6.5


    -6.5
    +270


    -290
    43
    SFO

     
    SFO

     
    DOG
    Road

     
    Under

    2004
    Dec 26
    Buffalo Bills Buffalo Bills
    San Francisco 49ers San Francisco 49ers
    41


    7
    -11


    +11
    -


    -
    42.5
    BUF

     
    BUF

     
    FAV
    Road

     
    Over

    2001
    Dec 2
    Buffalo Bills Buffalo Bills
    San Francisco 49ers San Francisco 49ers
    0


    35
    +8.5


    -8.5
    -


    -
    44
    SFO

     
    SFO

     
    FAV
    Home

     
    Under

    1998
    Oct 4
    San Francisco 49ers San Francisco 49ers
    Buffalo Bills Buffalo Bills
    21


    26
    -10


    +10
    -


    -
    45
    BUF

     
    BUF

     
    DOG
    HOME

     
    Over

    1995
    Dec 3
    Buffalo Bills Buffalo Bills
    San Francisco 49ers San Francisco 49ers
    17


    27
    +14


    -14
    -


    -
    46.5
    SFO

     
    BUF

     
    DOG
    Road

     
    Under

    1992
    Sep 13
    Buffalo Bills Buffalo Bills
    San Francisco 49ers San Francisco 49ers
    34


    31
    +3.5


    -3.5
    -


    -
    44.5
    BUF

     
    BUF

     
    DOG
    Road

     
    Over

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