Highmark Stadium

    8:20 PM ET (NBC)
    ScoreLineOURecordATSO-U-PPFPAEST ScoreEST Line
     49ers
    0
    -2
    3-43-4-04-3-025.722.6
    0
    0
     Bills
    0
    +2
    47
    5-24-3-04-3-028.419.4
    0
    0



    2024 Recent Results
    San FranciscoDraftKingsResultsMoney LineSpreadOVER Total
    WkDateOpponentMLLineOUScoreSUATSOUHandleBetsHandleBetsHandleBets
    Oct 20 VS  Kansas City
    -142
    -2.5
    48
    18-28
    L
    L
    U
    48%
    32%
    52%
    39%
    74%
    67%
    Oct 10 at  Seattle
    -198
    -4
    49
    36-24
    W
    W
    O
    66%
    66%
    59%
    61%
    53%
    49%
    Oct 6 VS  Arizona
    -340
    -7.5
    49
    23-24
    L
    L
    U
    74%
    88%
    47%
    50%
    77%
    65%
    Sep 29 VS  New England
    -575
    -10.5
    42.5
    30-13
    W
    W
    O
    71%
    91%
    50%
    50%
    34%
    44%
    Sep 22 at  LA Rams
    -258
    -6
    44.5
    24-27
    L
    L
    O
    80%
    87%
    64%
    64%
    33%
    48%
    Sep 15 at  Minnesota
    -218
    -4.5
    46.5
    17-23
    L
    L
    U
    87%
    93%
    75%
    85%
    62%
    64%
    Sep 9 VS  NY Jets
    -192
    -3.5
    43
    32-19
    W
    W
    O
    48%
    67%
    48%
    57%
    67%
    56%

    2024 Recent Results
    BuffaloDraftKingsResultsMoney LineSpreadOVER Total
    WkDateOpponentMLLineOUScoreSUATSOUHandleBetsHandleBetsHandleBets
    Oct 20 VS  Tennessee
    -535
    -9.5
    41
    34-10
    W
    W
    O
    90%
    96%
    71%
    75%
    79%
    79%
    Oct 14 at  NY Jets
    -120
    -1
    42.5
    23-20
    W
    W
    O
    48%
    65%
    67%
    77%
    60%
    67%
    Oct 6 at  Houston
    +102
    +1.5
    48
    20-23
    L
    L
    U
    58%
    64%
    58%
    66%
    75%
    81%
    Sep 29 at  Baltimore
    +114
    +2.5
    47.5
    10-35
    L
    L
    U
    45%
    57%
    45%
    58%
    76%
    76%
    Sep 23 VS  Jacksonville
    -225
    -4.5
    46.5
    47-10
    W
    W
    O
    58%
    81%
    67%
    77%
    55%
    59%
    Sep 12 at  Miami
    +114
    +2.5
    49
    31-10
    W
    W
    U
    54%
    58%
    42%
    45%
    74%
    75%
    Sep 8 VS  Arizona
    -325
    -6.5
    46
    34-28
    W
    L
    O
    62%
    86%
    54%
    61%
    77%
    63%

    Last 5 Head to Head Results
    DateRoad/HomeScoreLineMLOUSUATSF/DH/AOU

    2020
    Dec 7
    San Francisco 49ers San Francisco 49ers
    Buffalo Bills Buffalo Bills
    24


    34
    +2.5


    -2.5
    +119


    -
    48
    BUF

     
    BUF

     
    FAV

    Over

    2016
    Oct 16
    San Francisco 49ers San Francisco 49ers
    Buffalo Bills Buffalo Bills
    16


    45
    +7.5


    -7.5
    +280


    -345
    44
    BUF

     
    BUF

     
    FAV
    HOME

     
    Over

    2012
    Oct 7
    Buffalo Bills Buffalo Bills
    San Francisco 49ers San Francisco 49ers
    3


    45
    +10


    -10
    +395


    -475
    45.5
    SFO

     
    SFO

     
    FAV
    Home

     
    Over

    2008
    Nov 30
    San Francisco 49ers San Francisco 49ers
    Buffalo Bills Buffalo Bills
    10


    3
    +6.5


    -6.5
    +270


    -290
    43
    SFO

     
    SFO

     
    DOG
    Road

     
    Under

    2004
    Dec 26
    Buffalo Bills Buffalo Bills
    San Francisco 49ers San Francisco 49ers
    41


    7
    -11


    +11
    -


    -
    42.5
    BUF

     
    BUF

     
    FAV
    Road

     
    Over