Highmark Stadium

    8:20 PM ET (NBC)
    ScoreLineOURecordATSO-U-PPFPAEST ScoreEST Line
     49ers
    0
    -2
    1-11-1-01-1-024.521.0
    0
    0
     Bills
    0
    +2
    47
    2-01-1-01-1-032.519.0
    0
    0



    2024 Recent Results
    San FranciscoDraftKingsResultsMoney LineSpreadOVER Total
    WkDateOpponentMLLineOUScoreSUATSOUHandleBetsHandleBetsHandleBets
    Sep 15 at  Minnesota
    -218
    -4.5
    46.5
    17-23
    L
    L
    U
    87%
    93%
    75%
    85%
    62%
    64%
    Sep 9 VS  NY Jets
    -192
    -3.5
    43
    32-19
    W
    W
    O
    48%
    67%
    48%
    57%
    67%
    56%

    2024 Recent Results
    BuffaloDraftKingsResultsMoney LineSpreadOVER Total
    WkDateOpponentMLLineOUScoreSUATSOUHandleBetsHandleBetsHandleBets
    Sep 12 at  Miami
    +114
    +2.5
    49
    31-10
    W
    W
    U
    54%
    58%
    42%
    45%
    74%
    75%
    Sep 8 VS  Arizona
    -325
    -6.5
    46
    34-28
    W
    L
    O
    62%
    86%
    54%
    61%
    77%
    63%

    Last 5 Head to Head Results
    DateRoad/HomeScoreLineMLOUSUATSF/DH/AOU

    2020
    Dec 7
    San Francisco 49ers San Francisco 49ers
    Buffalo Bills Buffalo Bills
    24


    34
    +2.5


    -2.5
    +119


    -
    48
    BUF

     
    BUF

     
    FAV

    Over

    2016
    Oct 16
    San Francisco 49ers San Francisco 49ers
    Buffalo Bills Buffalo Bills
    16


    45
    +7.5


    -7.5
    +280


    -345
    44
    BUF

     
    BUF

     
    FAV
    HOME

     
    Over

    2012
    Oct 7
    Buffalo Bills Buffalo Bills
    San Francisco 49ers San Francisco 49ers
    3


    45
    +10


    -10
    +395


    -475
    45.5
    SFO

     
    SFO

     
    FAV
    Home

     
    Over

    2008
    Nov 30
    San Francisco 49ers San Francisco 49ers
    Buffalo Bills Buffalo Bills
    10


    3
    +6.5


    -6.5
    +270


    -290
    43
    SFO

     
    SFO

     
    DOG
    Road

     
    Under

    2004
    Dec 26
    Buffalo Bills Buffalo Bills
    San Francisco 49ers San Francisco 49ers
    41


    7
    -11


    +11
    -


    -
    42.5
    BUF

     
    BUF

     
    FAV
    Road

     
    Over