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Monday,December 22

49ers at

Lucas Oil Stadium

8:15 PM ET (ESPN)	Score	Line	OU	Record	ATS	O-U-P	PF	PA	EST Score	EST Line
49ers	0	-3		9-4	8-5-0	7-6-0	23.6	20.7	0	0
Colts	0	+3	46.5	8-4	7-5-0	6-6-0	29.8	20.8	0	0

San Francisco 49ers Indianapolis Colts Head to Head

2025 Recent Results

Wk	Date	Opponent	ML	Line	OU	Score	SU	ATS	OU	Handle	Bets	Handle	Bets	Handle	Bets
San Francisco			DraftKings			Results				Money Line		Spread		OVER Total
13	Nov 30	at Cleveland	-250	-5.5	35.5	26-8	W	W	U	64%	76%	55%	52%	35%	62%
12	Nov 24	VS Carolina	-395	-7.5	49.5	20-9	W	W	U	63%	83%	46%	51%	74%	53%
11	Nov 16	at Arizona	-185	-3.5	48.5	41-22	W	W	O	92%	88%	72%	75%	68%	40%
10	Nov 9	VS LA Rams	+210	+5.5	49.5	26-42	L	L	O	32%	22%	40%	48%	52%	53%
9	Nov 2	at NY Giants	-148	-2.5	47.5	34-24	W	W	O	72%	76%	73%	75%	56%	39%
8	Oct 26	at Houston	+130	+2.5	41.5	15-26	L	L	U	42%	77%	29%	71%	82%	67%
7	Oct 19	VS Atlanta	-115	-1.5	46.5	20-10	W	W	U	49%	52%	57%	55%	74%	56%
6	Oct 12	at Tampa Bay	+164	+3.5	47.5	19-30	L	L	O	40%	27%	51%	46%	87%	75%
5	Oct 2	at LA Rams	+350	+7.5	43.5	26-23	W	W	O	20%	16%	43%	43%	60%	50%
4	Sep 28	VS Jacksonville	-180	-3.5	45.5	21-26	L	L	O	57%	78%	25%	54%	60%	35%
3	Sep 21	VS Arizona	-122	-1.5	44.5	16-15	W	L	U	52%	61%	64%	58%	69%	64%
2	Sep 14	at New Orleans	-166	-3	40.5	26-21	W	W	O	66%	80%	69%	72%	53%	46%
1	Sep 7	at Seattle	-135	-2.5	43.5	17-13	W	W	U	62%	71%	64%	65%	64%	59%

2025 Recent Results

Wk	Date	Opponent	ML	Line	OU	Score	SU	ATS	OU	Handle	Bets	Handle	Bets	Handle	Bets
Indianapolis			DraftKings			Results				Money Line		Spread		OVER Total
13	Nov 30	VS Houston	-170	-3	44.5	16-20	L	L	U	54%	68%	52%	55%	31%	47%
12	Nov 23	at Kansas City	+185	+4.5	50.5	20-23	L	W	U	28%	44%	37%	58%	39%	49%
10	Nov 9	(n) Atlanta	-310	-6.5	48.5	31-25	W	L	O	64%	89%	63%	70%	68%	48%
9	Nov 2	at Pittsburgh	-175	-3	51.5	20-27	L	L	U	53%	76%	51%	69%	75%	66%
8	Oct 26	VS Tennessee	-1600	-15.5	47.5	38-14	W	W	O	66%	93%	71%	67%	72%	59%
7	Oct 19	at LA Chargers	+120	+2.5	49.5	38-24	W	W	O	32%	60%	44%	57%	76%	66%
6	Oct 12	VS Arizona	-455	-8.5	46.5	31-27	W	L	O	80%	91%	68%	67%	64%	62%
5	Oct 5	VS Las Vegas	-360	-7	46.5	40-6	W	W	U	79%	92%	67%	65%	84%	60%
4	Sep 28	at LA Rams	+154	+3.5	49.5	20-27	L	L	U	39%	32%	57%	51%	77%	64%
3	Sep 21	at Tennessee	-250	-6	42.5	41-20	W	W	O	83%	90%	62%	62%	51%	70%
2	Sep 14	VS Denver	+105	+1.5	43.5	29-28	W	W	O	55%	37%	44%	34%	54%	52%
1	Sep 7	VS Miami	-112	-1.5	47.5	33-8	W	W	U	52%	30%	36%	30%	47%	41%

Last 5 Head to Head Results

Date	Road/Home	Score	Line	ML	OU	SU	ATS	F/D	H/A	OU
2021 Oct 24	Indianapolis Colts San Francisco 49ers	30 18	+3.5 -3.5	+165 -190	41.5	IND	IND	DOG	Road	Over
2017 Oct 8	San Francisco 49ers Indianapolis Colts	23 26	+1 -1	+100 -120	44	IND	IND	FAV	HOME	Over
2013 Sep 22	Indianapolis Colts San Francisco 49ers	27 7	+10.5 -10.5	+390 -500	45.5	IND	IND	DOG	Road	Under
2009 Nov 1	San Francisco 49ers Indianapolis Colts	14 18	+12.5 -12.5	+575 -725	45	IND	SFO	DOG	Road	Under
2005 Oct 9	Indianapolis Colts San Francisco 49ers	28 3	-16.5 +16.5	- -	45.5	IND	IND	FAV	Road	Under

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